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In addition to transporter blockade, imipramine exhibits antagonism at multiple receptors, including muscarinic (M1), histamine (H1), and 1-adrenergic receptors, contributing to both therapeutic and adverse effects

Ponzetto C, Bardelli A, Maina F, Longati P, Panayotou G, Dhand R, Waterfield MD, Comoglio PM

These results differ from the effects of GIP(3-30)NH 2 in non-operated individuals, and points to a less important role of GIP in glucose metabolism after gastric bypass surgery (79, 92)

These medications regulate blood sugar, promote fullness, and support weight loss by mimicking hormones that stimulate insulin release